The way you express trans-humanist goal reminds me of a few sentences at the end of the Abolition of Man (C.S. Lewis). He seems to acknowledge the march of Science as inevitable, but he laments that the reductive explanations tend to tear down all that is sacred and ourselves too. He wishes for a kind of science that explains in a way that builds up meaning rather than obliterating it. He finishes that thought by noting that he hardly knows what he is asking for.

But I have a glimmer.... if all things ultimately have no meaning, then the word "meaning" itself has no useful meaning, and we need a more useful framing.